Are you time-bombing your ta-tas?
February 28th, 2011
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by Heather · Filed Under: General Health · Ponderings
Today’s post is inspired by this Science Daily article–> Key Culprit identified in breast cancer metastasis
As the proud owner of two breasts, this stuff piques my interest. As the female member of a family prone to breast cancer, this stuff really gets my attention. And as someone who never got to meet her maternal grandmother who died of breast cancer WAY too early (she was 28, my mother only being 3 at the time), I can’t help but read this stuff and think: “What if…?” {sigh}
So on to the gist of the article. Things you need to know first (much of it quoted directly from the article above):
- Regulatory T cells = cells found in tumors of breast cancer patients, these cells’ job is to help mediate the body’s immune response
- RANKL=an inflammatory protein normally involved in bone remodeling (note: high turnover is the name of the game with bone cells), high levels of it make lab mice with breast cancer more prone to developing metastatic lung cancer
- Regulatory T cells produce RANKL, which appears to hasten and intensify the spread of breast cancer to distant organs and, in doing so, dramatically increase the risk of death
- The studies mentioned were done on mice. (Animal studies make me cringe too.) And we’re not mice, we’re humans, so keep that mind.
Researchers figured out RANKL’s role by injecting synthetic RANKL into the tumors of breast cancer mice, and noticed that it made the cancer spread like wildfire. Since RANKL was already known to have an effect of slowing bone loss in post-menopausal women, researchers tried a RANKL-inhibiting drug on the breast cancer mice and noticed that it controlled metastasis of the cancer to other body tissues. Interesting.
But what I personally found more interesting was this: “Other breast cancer studies have linked RANKL to early stages in the development of synthetic progestin-driven breast tumors. According to the Women’s Health Initiative and the Million Women Study, hormone replacement therapy and contraceptives with progestin significantly increase the risk of developing breast cancer.” If you take birth control pills or hormone replacement therapy that use synthetic progestins, this should have your attention, particularly if you or your family members have a history of breast cancer. It’s been long known that synthetic hormone use can predispose people to cancer, especially when compounded by advanced age, genetic predisposition, poor lifestyle choices like smoking, etc. But this information indicates at least one reason why this is so. Likewise, inflammation is known to be at the base of many (some would say all) diseases. Medications inflame the body. The efficacy of synthetic hormones versus bioidenticals is controversial. So it just all makes sense. What it also does is keep me up at night when I think of so many patients and friends taking these types of hormones.

I have a very close friend who deals with devastating migraines and menstrual pain. BC pills help control those things but she wants off because of what she knows as a health professional. What’s a thinking girl who wants optimal health and longevity to do?
Food for thought, comments welcome of course. Some things to consider below. Please add yours.:
- Does this mean that some day with your new prescription of birth control or HRT, you’ll also get a prescription for a RANKL-inhibiting drug, just to hopefully cover a base?
- What happens if, out of fear, legions of women toss the birth control pills out the window in favor of other methods? (Think about things like potentially: higher pregnancy rates; lower STD rates; higher rates of things that women control via birth control pills or HRT like migraines, cramps, acne; lower rates of some cancers; lower infertility rates; etc.)
Disclaimer: This blogpost is just that–a blogpost. This one in particular is just a discussion of the article linked at the top. Do not, under any circumstances. take anything written here as “medical advice”. To that end, do not discontinue use of, decrease or increase dosage of, or otherwise change your prescribed medication(s) without medical advice and supervision. If you have questions or concerns about any questions raised due to this post or any comments about the post, contact your medical care provider.
In memory of my biological maternal grandmother, Margaret (”Marge”) Ryba Mack. I’m sorry we missed out on each other. I’m sure I would have loved you.



















